PARP1 and CBP lose their footing in cancer

Nature Structural & Molecular Biology, 2014, doi:10.1038/nsmb.2913, 21, 947–948 published on 05.11.2014
Nature Structural & Molecular Biology, online article
The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.

TU München
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MPI of Biochemistry