Soft skills turned into hard facts: nucleosome remodelling at developmental switches

Heredity, 2010, 105, 71 - 79 published on 01.07.2010
Heredity, online article
Nucleosome remodelling factors are regulators of DNA accessibility in chromatin and lubricators of all major functions of eukaryotic genomes. Their action is transient and reversible, yet can be decisive for irreversible cell-fate decisions during development. In addition to the well-known local actions of nucleosome remodelling factors during transcription initiation, more global and fundamental roles for remodelling complexes in shaping the epigenome during development are emerging.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry