Research Area F - Publications 2018
Annual Review of Neuroscience, Vol. 41:277-297, https://doi.org/10.1146/annurev-neuro-080317-061725
Annual Review of Neuroscience, online article
A major mystery of many types of neurological and psychiatric disorders, such as Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage. Because of the strong interconnectivity of neurons in the brain, neuronal dysfunction necessarily disrupts neuronal circuits. In this article, we review evidence for the disruption of large-scale ...
Neuron, 99, 1–9, https://doi.org/10.1016/j.neuron.2018.05.021
Neuron, online article
The ability to remember and to navigate to safe places is necessary for survival. Place navigation is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However, learning-dependent changes in neuronal activity in the distinct circuits remain unknown. Here, by using optic fiber photometry in freely behaving mice, we discovered the ...
Front. Cell. Neurosci., https://doi.org/10.3389/fncel.2018.00111
Front. Cell. Neurosci., online article
The Mongolian gerbil (Meriones unguiculatus) is widely used as a model organism for the human auditory system. Its hearing range is very similar to ours and it uses the same mechanisms for sound localization. The auditory circuits underlying these functions have been characterized. However, important mechanistic details are still under debate. To elucidate these ...
Front. Mol. Neurosci., Volume 10, Article 436, doi: 10.3389/fnmol.2017.00436
Front. Mol. Neurosci., online article
Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's ...
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis
J. Cell Biol., Volume 217, No. 1, https://doi.org/10.1083/jcb.201706021
J. Cell Biol., online article
During cytokinesis, a signal from the central spindle that forms between the separating anaphase chromosomes promotes the accumulation of contractile ring components at the cell equator, while a signal from the centrosomal microtubule asters inhibits accumulation of contractile ring components at the cell poles. However, the molecular identity of the inhibitory ...
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa
Front. Immunol., Volume 8, Article 1930, https://doi.org/10.3389/fimmu.2017.01930
Front. Immunol., online article
Retinitis pigmentosa (RP) denotes a family of inherited blinding eye diseases characterized by progressive degeneration of rod and cone photoreceptors in the retina. In most cases, a rod-specific genetic defect results in early functional loss and degeneration of rods, which is followed by degeneration of cones and loss of daylight vision at later stages. ...