What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?
A Visual-Cue-Dependent Memory Circuit for Place Navigation
Optogenetic Control of Neural Circuits in the Mongolian Gerbil
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes
AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye
Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division
An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
Small Molecules for Early Endosome-Specific Patch Clamping
Partners in Crime
Photopharmacological control of bipolar cells restores visual function in blind mice
BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE
AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants
Linking Neurons to Network Function and Behavior by Two-Photon Holographic Optogenetics and Volumetric Imaging
Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency
Quantitative LC–MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues
Gene therapy for achromatopsia
Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions
miRNAs cooperate in apoptosis regulation during C. elegans development
In vivo deep two-photon imaging of neural circuits with the fluorescent Ca2+ indicator Cal-590
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells
Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone
Improved deep two-photon calcium imaging in vivo
Quantifying macromolecular interactions in living cells using FRET two-hybrid assays
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination
The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region
Super-resolution microscopy writ large
Programmed Cell Death During Caenorhabditis elegans Development
AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments
Photoswitchable diacylglycerols enable optical control of protein kinase C
Imaging of neuronal mitochondria in situ
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
Impairments of neural circuit function in Alzheimer's disease
Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy
Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice
Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response
In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology
Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors
A family of photoswitchable NMDA receptors
Entrapment of Water at the Transmembrane Helix–Helix Interface of Quiescin Sulfhydryl Oxidase 2
Deadly dowry: how engulfment pathways promote cell killing
HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure
In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors
Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)
Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology
Synthetic approaches towards alkaloids bearing α-tertiary amines
Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter
Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist
Rescue of long-range circuit dysfunction in Alzheimer's disease models
The loss of LRPPRC function induces the mitochondrial unfolded protein response
Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ‑Secretase
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif
An eight-step synthesis of epicolactone reveals its biosynthetic origin
Optical control of NMDA receptors with a diffusible photoswitch
Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator
Role of GxxxG Motifs in Transmembrane Domain Interactions
Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotyp
Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death
Azobenzene-based inhibitors of human carbonic anhydrase II
Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues
TRPC3‐dependent synaptic transmission in central mammalian neurons
Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice
cGMP/PKG Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of CNG Channel-Deficient Mice
Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3−/−/Nrl−/− mice, an all-cone model of CNGA3 achromatopsia
Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications
Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice
Synthetic Studies toward Polytwistane Hydrocarbon Nanorods
A recoverable state of axon injury persists for hours after spinal cord contusion in vivo
DNA methylation and differential gene regulation in photoreceptor cell death
Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation
Pathological a-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen
Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan
Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)
Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model
Gene Therapy Restores Vision and Delays Degeneration in the CNGB1-/- Mouse Model of Retinitis Pigmentosa
Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
Inhibition of mitochondrial fusion by Alpha-synuclein is rescued by PINK1 Parkin and DJ-1
Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease beta - and gamma-Secretase via Distinct Mechanisms
Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
Sparsification of neuronal activity in the visual cortex at eye-opening
Hyperpolarization-Activated Cation Channels: From Genes to Function
Vision tests in the mouse: Functional phenotyping with electroretinography
Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain
Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Regulatory RNA goes awry in Alzheimer’s disease
Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b
Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models
Endoplasmic reticulum retetion of the gamma-secretase complex component Pen2 by Rer1
The Nicastrin-like Protein Nicalin Regulates Assembly and Stability of the Nicalin-Nodal Modulator (NOMO) Membrane Protein Complex
Show Organigram
